01 / Introduction

Most regulatory delays trace back to CMC documentation.

BioPrism is a CMC-native AI platform that turns experimental data and manufacturing records into submission ready regulatory documents. Across the biopharma development lifecycle, BioPrism reduces months of manual compliance work to days.

Built by CMC Practitioners Merck, AstraZeneca, Spark, Passage Bio
CTD Module 3 / Drug Substance
S.1 S.2 S.3 S.4 S.5 S.6 S.7
02/The Cost of the Status Quo

The hidden cost of CMC documentation gaps.

Each one points to the same gap: documentation that isn't ready when the science is.

74%1
of FDA Complete Response Letters cite manufacturing or quality issues.
20-50%2
of IND submissions face clinical holds tied to incomplete CMC data.
8.4 mo3
average time to resolve a single CMC inquiry during FDA review.

1FDA CRL release via openFDA, July 2025; analysis by Pharma Manufacturing.

2Industry analyses of public FDA IND clinical hold data.

3Industry benchmark; published CMC review timelines.

03/The Platform

Built for CMC, end to end.

Source documents to submission-ready CMC sections. With traceability and review built in.

BioPrism flow: Upload Data, BioPrism AI Engine, Submission Ready Documents
04/Where the Time Goes

Less time on writing. The same time on review.

BioPrism shifts expert effort to where it matters. Authoring collapses. Review and judgment do not.

Manual
Writing
Review
BioPrism
Write
Review
<70%

less time on CMC authoring. Experts focus on review and judgment, not first drafts.

05/Why Now

The industry is shifting.
The infrastructure has not caught up.

Biopharma teams face structural changes in how regulatory documentation must be authored, exchanged, and validated. BioPrism is built for what comes next.

05.01

Structured authoring is the new baseline

Emerging regulatory frameworks require structured, machine readable submissions. Legacy authoring tools cannot meet them.

05.02

Pipeline volume is outpacing CMC capacity

More candidates, the same documentation headcount. CMC has become the gating function for clinical timelines.

05.03

AI is finally credible in regulated workflows

Domain specific, controlled AI systems can now meet the audit and traceability standards regulators expect.

06/Who Built It

Built by people who have lived the problem.

BioPrism is built by a team of CMC, regulatory, and AI/ML practitioners. The founding team brings 20+ years of regulatory and manufacturing experience across Merck, AstraZeneca, Spark Therapeutics, and Passage Bio, including active authorship of a gene therapy BLA currently under FDA review.

The technical foundation is built by senior machine learning engineers with two decades of large scale ML leadership at Amazon, Coinbase, Barclays, and JPMorgan. Domain depth is reinforced by senior CMC and analytical practitioners and a scientific advisory board with biologics and gene therapy expertise.

Merck
AstraZeneca
Spark Therapeutics
Passage Bio
Amazon
Coinbase
Barclays
JPMorgan

See what regulatory documentation looks like when it is built right.

Request a Demo

For biopharma teams across drug development